Ethics of Gene Therapy Case Study Example | Topics and Well Written Essays - 1250 words

Ethics of Gene Therapy - Case Study Example The term cloning encompasses three different procedures leading to different results. These are embryo cloning (artificial twinning), adult DNA cloning (reproductive cloning) and therapeutic cloning (bio medical cloning). Of these three, therapeutic cloning seems to hold the maximum potential to breed humans (read human cloning). Human cloning is most aptly described as breeding humans for the purpose of harnessing tissues and organs from their bodies. Therapeutic cloning begins with the insertion on a human DNA into an ovum. A pre embryo is formed by giving electric shocks to the resultant ovum. The stem cells from the developed pre embryo are then extracted and subsequently provided an suitable environment where they develop into the required tissue or organ. These experiments are yet to produce any significant results. Once accomplished, the aim of developing organs or tissues which perfectly match with the recipient will be realized eliminating the fatal risk of rejection because the organ will be based on the recipient's genetic material. Human cloning is also expected to make new breakthroughs in rejuvenation, heart attack reversals, diabetics, leukemia, genetic disorders and even cancer. Despite the broad spectrum of benefits that human cloning offers, according to a poll, "63% believed that human cloning is against God's will and 90% considered it to be a bad idea" (Times, 2001). A Morgan poll conducted during November 2001 found that 70 percent of Australians aged 14 and over approved of extracting stem cells from human embryos to treat disease and injury. Seventy percent also believed that couples with excess embryos after infertility treatment should be able to donate them to research rather than discard them. However, when it came to using a patient's own genetic material to create a cloned embryo to be used as a source of stem cells (i.e. therapeutic cloning), just over half (55 percent) of the respondents approved, with 32 percent disapproving and 13 percent undecided (Morgan Poll, 2001).Animal cloning application as a regular process should be prevented and breeding of humans should also be strongly opposed to maintain the natural uniqueness of each individua l (Church of Scotland, 1997). These objections are not absolutely without any reasons. They do have apt explanations and sufficient grounds. Human cloning would produce a gamut of clones with reduced mental abilities and enhanced physical strengths which would make then highly susceptible to exploitation. Producing designer babies with enhanced skills would also lead to an excess of skilled persons thus decreasing the importance of talent and skill. Human cloning may also lead to emotional difficulties in the clone human's life. A child born from his father's DNA would in effect be a twin of his own father. This can also lead to a high degree of conundrum. There is no guarantee that human clones would be normal and they might even be suffering with life long disabilities. Any minor flaws while incorporating certain characteristics could as well create fictional monsters. Tampering with nature to an

Review Essay Example | Topics and Well Written Essays - 1000 words - 4

Review - Essay Example He goes on to explain that there are possibilities for a wrongful diagnosis that then poses the question what do the parents do with the information? Is it ethical for a parent to make the decision for their child’s life when a mutation in a gene does not necessarily prove they will contract the disease? David Devore was a participant in the Woodrow Wilson Biology Institute where he conducted much research on the topic in this article. He has extensive knowledge in genetics and has provided a lot of detailed information from many other sources. Devore believes genetic screening for diseases such as Lesch-Nyhan syndrome which causes mental retardation after the first few days of life is necessary and beneficial to both the parents and the offspring but that screening for diseases like alcoholism or Alzheimer’s is not beneficial and may be detrimental to the child’s life. Even though a child may possess the gene responsible for the disease does not mean they will contract it. Therefore Devore believes genetic counseling should also be available after the results are received. I chose this source because it not only describes the techniques of genetic screening but also the positives and negatives of screening for different diseases and the consequences of both choices. I t provides rich information on my argument as to whether it is ethical to conduct these tests and the consequences of the parents’ decisions based on that information. I found this source on the internet in another institution publication. The only thing missing are first-hand accounts from individuals. The article â€Å"Genetic Screening, the Social Impact of Genetic Knowledge† by Boris Sagredo describes the process of genetic screening and the use of assays to compare individuals in a population to determine a difference in the genes. Although genetic screening can predict a possibly contraction of a disorder based on the

The Health Industry Of Malaysia Health And Social Care Essay

The Health Industry Of Malaysia Health And Social Care Essay Obesity has emerged as a big issue in most countries. Countries such as Malaysia has identified this problem as one of the burden in health care system, which it has been linked to high mortality and morbidity related disease in many private and government hospital. Formally obesity is assume as a symbol of wealth, prosperity and health, but on this day it has been an enormous threat to the future generations where most of them died of complications due to overeating and not starve to death. The prevalence of obesity realted disease in this country has leading to a rapid increase of incident in chronic disease. According to Health Ministry statistics, heart disease is the third leading cause of deaths of patients in this country. If compared to the same statistics in countries that have developed as Western Europe, the United States and Japan, the leading cause of death in their country was cardiovascular disease. This clearly indicates that we were moving towards westernization in e xperiencing the same problem face by the developed countries. As we know obesity is a problem that will lower the quality of life and the leading causes of many chronic diseases in later life. Myres (2002) state that obesity is an excess of body fat that frequently results in a significant impairment of health. Unfortunately this problem should not be the cause of death if they have little knowledge about the disease and raising awareness about obesity. Thus it is not surprising the number of obesity has increase every year because of their ignorance and lack of public understanding about the cause of obesity. Working with an environment that tends to lead my patients become into obese has made me aware of my responsible to take part in battling this issue before it become into a heavy burden on my health care system. Over all my paper will not only focus on my patient, but also to the society as well on the consequences of obesity in term of health and economic cost that will indeed occur if there is no immediate action taken. Besides that, I will also explore in depth on how this issue can be a complication-related lifestyle and recommendations for re-appraise our own practices accordingly. Body Obesity is a condition where a person has excessive body weight due to accumulation of fat in the body. Obesity results when the size or number of fat cells in a persons body increases Myers (2004). Obesity is usually assessed by using Body Mass Index (BMI) and the level of obesity is a global standard of classification of respondents either underweight, ideal weight, overweight and obese. BMI is calculated by dividing a persons weight in kilograms by height (in M  ²). A BMI of 18.5 to 22.9 consider as normal, 23 to 27.4 as pre-obese and above 27.5 is to overweight (obese). According to BMI standards, individuals are said to be overweight when BMI is between 25.0->40kg / m ² (Ismail I S elt. 2004). Generally, from the observations that has been made on my patients founds that not all of them eat more than the amount consumed by their body weight was obese, but what is for sure those who are obese eating more than what is needed by their body and most of them who are obese are mor e significant to get the disease-related obesity than those with normal body weight. Listen Read phonetically World Health Organization estimates that by 2015, roughly 2.3 billion people in the world will have more weight and 700 million people worldwide will suffer obesity (National consumer Campaign 2010). More worsen, this phenomenon will continue growing into an epidemic and spread to most developing countries. Malaysia is a Southeast Asian country which has the second highest obesity in population. According to National Health Morbidity Survey (2006) found that 29% of Malaysian adults were overweight and 14% are obese, which mean 43% of Malaysian adults (or 2 in 5) are overweight. Compared with the 10 years back the survey reported that 17% (or 1 in 5) of Malaysian adults were overweight and another 4% were obese. Through the differences over the 10-year period, the increasing of overweight among Malaysians had clearly had jumped into 70% and more surprising obesity has risen to 250%. Thats why it has become a serious concern for the ministry to confronting this issue, which it has lea d to many chronic disease including renal failure in Malaysia. In my dialysis center, diabetes mellitus and hypertension were the main causes of my patients are been diagnosed with kidney disease and most of them also have excessive body weight. Although they have been diagnosed with diabetes and hypertension disease, many of them are still ignoring the daily diet and proper nutrition for them. As a result, mortality of chronic diseases becomes higher in my center. Causes Dealing with obesity, what actually cause the problem to occur? To answer these questions, we need to look at the factors that can cause obesity. According to health experts, based on the results of the study, obesity can be influenced by various factors. These factors are among genetic factors, gender, excessive eating patterns, lack of sports motion, emotion, and environmental factors. So far there has been no strong evidence and data available linking gender and genetic is the main contributors to obesity in my center. However through my experience which almost 10 years shows that obesity is more likely linked with the lifestyle and environment compared to other factors. Many experts believe that this factor does have a significant impact in contributor the cause of obesity in developing countries. Swallen KC, elt (2005) found the results of his research shows that obesity is closely linked with the unhealthy quality of life. WHO (2003) also noted that the leading factor are incre ased consumption of energy-dense foods high in saturated fats and sugars, and reduced physical activity. Thats why I find that excessive sugar intake in beverages and food will certainly lead to diabetes and if this problem is not treated immediately, patients may require dialysis to survive, because of kidney failure.Listen Read phonetically As the populations become urbanization, the increase in the standard of living and modernization in most countries is usually accompanied by increase in weight gain and obesity. Young people in socio-economic groups are more likely concerned with their career as demanding on hardworking has been a necessity in worldwide. At the same time, dependence on automated technology such as elevator facilities or modern transportation has reduce of their physical activity. In childhood obesity is already become a serious concern in Malaysia whereby obesity related complication also on rise among the them. According to Lim Y N elt. (2008) in 2006, the dialysis incident rate for age Genetic factors also play a big role in contributing to the risk of obesity where it can be inherited from the previous generation to the next generation in a family. Some individuals appear to be born with a genetic predisposition to obesity that is readily nurtured by our nations lifestyle (Thomas A. 2002). The most prominent feature of childhood obesity are other family members also face the similar problems and this usually is caused by a genetic defect called Lawrence Moon syndrome Biedl, syndrome. However, this doesnt mean that if there are families members who are obese and suffer from diabetes or hypertension, the other family members are not necessarily will get kidney disease. Implication Obesity is not a trivial issue. Its a health hazard. One of the major problems that will faced by the obesity children are insulin resistance and metabolic syndrome as stated by Kelishadi (2007) metabolic syndrome is also higher among the adult population in Asia. WHO (2002) as well reported that overweight and obesity also lead to adverse metabolic effect on blood pressure, cholesterol, triglycerides and insulin resistance. Risk of coronary heart disease, ischaemic stroke and type 2 diabetes mellitus increase steadily with increasing BMI. This clearly shows that the obesity is one of the primary factors causing of all this chronic disease and associated with increased risk of death. In Malaysia especially in the dialysis center, the epidemic of chronic diseases have been seen to increased rapidly than expected, which almost doubled over the last decade. I find that many of my patients have diabetes and hypertension before this and up until they had suffering from kidney failure. According to The Star (2010), there is over 14.9% of Malaysian population aged above 30 are suffer from diabetes and hypertension respectively which has increase from 8.3% in 1996. While 20.7% of adults aged over 18 will be at risk suffering from high cholesterol. Lim Y N elt. (2008) also stated that diabetes mellitus continues to be the commonest cause of renal failure and has been the cause of at least half of new dialysis patients since 2002. Hypertension was the second commonest known cause of renal failure at about 7%. However the main cause of death in renal failure patients is cause by cardiovascular disease which remained the main cause of the death in 2008, accounting for 29%. A ll of these scenario show that obesity is the commonest complication related to many chronic disease. As mentioned earlier this obese subjects also had a significant impact on the economy which, the government have to bear the increasing budget and long-term financial burden to organize the health programs and such medical treatment. According to WHO (2003), Obesity accounts for 2-6% of total health care costs in several developed countries; some estimates put the figure as high as 7%. The true costs are undoubtedly much greater as not all obesity-related conditions are included in the calculations. Cost to be borne by the patient to get dialysis treatment is also very high compared with other diseases as they requiring dialysis treatment for a lifetime. Kasemsup V elt. stated, in government perspective, the average cost for hemodialisis would be approximately 49 USD per session and total costs for access to HD (without erythropoietin injection) would range from 5,140 to 7,160 USD per case per year. Total costs for PD (without erythropoietin injection) would range from 4,640 to 7,280 USD per case per year. The estimates of costs for HD and PD are similar to costs for RRT in Malaysia. As well asListen Read phonetically health care today is also considered costing a lot of cost where as health care has been made as an economic activity. For young women, obesity becomes a problem serious enough, because of their desire to be perfect and slim is a dream for them. As a result, thousands dollars of money spent on diet, medications, and treatments for losing weight. As young men they are also afraid to be fat. For them, the fat man would be experiencing problems severe enough to attract the opposite sex. This of course will require a lot of money to be spent on a diet, buy slimming drugs and sports equipment just to reduce weight. Although they had to bear the burden in the battle against obesity and the disease, with the rapid economic growth and variety of health program organized by the government, has given them a better quality of life than the past.Listen Read phonetically Listen Read phonetically Policy Implementation of policy is very important in preventing this problem before it become into a catastrophic especially for the younger generation. Working in dialysis department has many advantages and potentials that can be done for patients to strengthen and maintain their healthy lifestyle. One of the programs in our policy here is health education, which it has a significant impact on their lifestyle. We always diversify the programs and measure they basic knowledge about the diseases and complication so they can make the wise decision to make changes in their cultural lifestyles and get help or counselling to deal with the problem of obesity. Greater emphasis on patient care also done through plan, organize, analyze and evaluate patients blood test results to determine the level of sugar and foods intake such as phosphate and potassium. The results of blood test are important to us to know their eating habits and thus the nutritional assessment can be made. The health system launched by the Ministry of Health Malaysia also very brave in implementing total transformation or make changes to the comprehensive strategy approach to combating the obesity of lifestyle. Promoting and improving weight management through programme Healthy Lifestyle Campaigns by the government has been running since 1991. However the most significant government policy in health promotion today is improving and focusing on the important of excercise, dietary habits and nutritional status under the National Nutrition Policy with the collaborations 10-year National Plan of Action for Nutrition from years 2006 to 2015. The government also has outlines the objectives, to plan and implement health promotion programmes and activities for the benefit of the community with a particular focus on youth. To fund and support sporting, recreational and cultural organizations to promote healthy lifestyles and healthy environments (Malaysian Health Promotion Board Act 2006). Recommendation Dealing to address the obesity should be made through the various aspects of approaches. Controlling eating and lack of exercise alone to achieve weight loss is not only the solution. From my past experience of public participation, it was found that the response of my patients and as well as the public to participate and understand the health programs that have been organized is very poor. The structure and guidelines with the goals, objectives and policies in form of a statement is often difficult to understand by them. As a result, their respond is very low in participation and certainly this implementation process will brings into questions on the effectiveness of health programs that can make aware of the community. Therefore, the existing campaign must be improved and intensified to convince them of the importance of health care. Health programs need to be restructured and reorganized in order to expand to the whole community, especially for the target group. Health policy shou ld be reviewed immediately in line with the increase of the disease and for a better outcome. To be more effective, I also recommend to my hospital for providing exercise facilities or fitness centres and free medical check up to attract them. Apart from that the Ministry must provide a large amount of expenditure for the purposes of promoting programs such as advertising programme, which its has own way in getting people excited about healthy lifestyle. The advertising programs that aim to reduce this burden also should be expanded and made easier for all levels of community to understand the message.Listen Read phonetically Listen Read phonetically But for the advertising of a variety of snack food products should be prohibited by the Ministry. Concerned about a toxic environment such as urban planning and junk food in schools only the act or the law alone can change the environment into a healthier and safer for the community. However, some of the contributing factors such as fat gene the thing that cannot change but of course they can work even harder to control their way of lifestyle. But what is the most important part of all is the involvement of all parties in addressing this epidemic become more wide. Listen Read phonetically Conclusion Generally, this disease has become a huge burden in my work place as well as in my country. With the available data, show that this issue frequently occur in developing country. By knowing the most common cause and incidence of the disease, we can understand how dangerous this scenario to the society. The high prevalence rate of this problem gave a lot of negative implications on health and economy, as the society are suppose to be the economic power and energetic generation in the future. However government has reinforced their strategy and target in combating this problem. Meanwhile health policy also should be reviewed immediately to improve for better public health outcomes. If these problems are not prevented from the very beginning can weaken the structure of society and become be a heavy burden on health care system as most young people will suffering many of the chronic disease. Therefore, obesity must be tackled as soon as possible before more and more Malaysians will experience it.

Breast Cancer Treatment Essay -- essays research papers fc

Breast Cancer Treatment   Ã‚  Ã‚  Ã‚  Ã‚  Only lung cancer kills more women each year in the United States than breast cancer does. The American Cancer Society (ACS) estimates that over 184,000 new cases of breast cancer were diagnosed in women in 1996 (ACS Breast). Although these statistics are alarming, there are a number of treatment options available for those that are diagnosed with breast cancer.   Ã‚  Ã‚  Ã‚  Ã‚  The best way to treat any disease is to prevent it. Since little is known about breast cancer, there are no established rules for prevention. The ACS recommends that women age twenty and older perform monthly breast self-exams, and it also suggests clinical examinations every three years (ACS Breast). Mammography is also a wonderful tool for detecting tumors; however, there is conflicting data on when and how often women should have mammograms. What is known is that mammography is the best way to determine if a palpable lump is actually cancerous or not.   Ã‚  Ã‚  Ã‚  Ã‚  Treatment methods for breast cancer can be lumped in two major categories; local or systemic. Local treatments are used to destroy or control the cancer cells in a specific area of the body. Surgery and radiation therapy are considered local treatments. Systemic treatments are used to destroy or control cancer cells anywhere in the body. Chemotherapy and hormonal therapy are considered systemic treatments.   Ã‚  Ã‚  Ã‚  Ã‚  Surgery is the most common treatment for breast cancer. Although there are many different types of breast cancer surgery, they all fit into a few basic categories. An operation that aims to remove most or all of the breast is called a mastectomy. If at all possible, doctors shy away from mastectomies due to the side effects which include loss of strength in the closest arm, swelling of the arm, and limitation of shoulder movement. If a mastectomy must be performed, the physician will often suggest post surgical reconstruction of the breast (Kushner 37).   Ã‚  Ã‚  Ã‚  Ã‚  Another type of breast cancer surgery is called breast-sparing surgery. This category would include lumpectomies and segmental mastectomies. In this situation, doctors remove only the tumor and make an attempt at sparing the rest of the breast tissue. These procedures are often followed by radiation therapy to destroy any canc... ...nbsp;  Ã‚  Ã‚  Contrary to the negative press commonly attributed to breast cancer, there are viable treatment options for those diagnosed with this terrible affliction. The push for increased research in breast cancer is even coming from the White House. President Bill Clinton mentioned his support for increased funding for research and prevention in his recent State of the Union Address, and he urged insurance companies to pay for more mammograms. Hopefully, with the support from the White House, new treatments can be found for breast cancer, and maybe with a little luck we will have a cure by the turn of the century. Works Cited American Cancer Society. Breast Cancer. Document 004070. American Cancer Society. For Women Facing Breast Cancer. 1995. Kushner, Rose. If You've Thought About Breast Cancer. Kensington, MD: Rose Kushner Breast   Ã‚  Ã‚  Ã‚  Ã‚  Cancer   Ã‚  Ã‚  Ã‚  Ã‚  Advisory Center, 1994. LaTour, Kathy. The Breast Cancer Companion. New York: William Morrow and Company, Inc., 1993. National Institutes of Health. National Cancer Institute. What You Need to Know About Breast   Ã‚  Ã‚  Ã‚  Ã‚  Cancer. Revised August 1995.

Recruitment Program

Sample generic health care provider recruitment plan It is imperative to have an all-encompassing recruitment policy for your organization. Sample recruitment policy: To develop a long-range recruitment plan; organize a recruiting schedule based upon the historical supply and demand for each major healthcare discipline; and implement the plan within the organization. A goal should be developed for each discipline (dentist, ancillary, hygienist, assistant). Sample goal: To recruit (number) dentists this year based on resignations, terminations, attrition or growth.Strategies, structure, and ongoing activities are important to the process. Sample strategies: To concentrate our efforts on health care professionals who are completing training programs, government obligations or military service. To anticipate the competition by contacting prospects early. To have a continuous, year-round schedule. Sample structure: The official recruiting cycle for program) will commence (Name of teachin g institution/ (Month and date) of each calendar year. All recruiting efforts within the institution will be coordinated through the human resources/personnel department/coordinator or his or her designed.The organization's recruitment committee will review the recruiting objectives no later than February 1 of each year. Sample of ongoing activities: Complete follow-up action with healthcare professionals who have interviewed. Schedule site visits for healthcare professionals from previous recruiting efforts. Obtain legal contracts for healthcare professionals who will commence practice. Recruitment committee will meet at least quarterly to review plan of action and develop strategies for implementation. Attend as many in-state health professional recruitment fairs as possible.Sample annual recruitment plan Quarterly Activities JANUARY – MARCH Survey active medical staff to determine: Provider needs/practices needing assistance Need for new practices in the community. Mail se cond recruitment letters to practicing dentists (first letter sent in October). Compile statistics from January medical staff survey. Prepare for initial provider/practice assessments. Complete follow-up action on providers who have completed site visits in December and January. Establish funding limits for calendar year from finance department. Prepare opportunity descriptions.Update printed recruitment materials. Identify residency programs and contact program directors/advisors. Identify recruitment conferences and exhibit possibilities. Meet with the provider recruitment committee to explain this year's campaign and their involvement (for example, interviews). Fine-tune the campaign with their input. Conduct initial provider/practice assessments to clarify provider recruitment needs in response to January medical staff survey. Mail second recruitment letter to next year's graduating students/professionals (first letter mailed in October). APRIL – JUNEBegin preparation for dental school marketing seminar (seminar about how to market practices and what to expect in recruiting). Meet with administrator to establish recruitment priorities. Send third recruitment letter to next year's graduating dental students. Semi-annual dental/provider manpower recruitment committee meeting. Assist newly recruited providers by facilitating their arrival and transition. JULY – SEPTEMBER Register a search with the DANNA and other placement services. Contact dentists in government service (National Health/Lillian Health Service Corps).Write other healthcare administrators in the region regarding a search for a healthcare provider for the community. Contact state licenser board for names of provider licensees and send letters to. Inform pharmaceutical and medical supply vendors of provider searches. Contact military installations in region for names of providers leaving service and ask about opportunities to communicate with them. Contact medical specialty associa tions to obtain information on meetings, publications and placement services. Identify provider recruitment opportunity fairs for the coming year.Dental school opportunity fair. Request dental school alumni affairs office to publicize opportunities. Post employment opportunities/vacancies with state health department, dental training programs and state primary-care associations. Obtain available provider computer lists for mailing to next year's graduating students. Visit dental training programs. Contact military dentists younger than 45 years. Send fourth recruiting letter to graduating students (in final year). Conduct consumer research to further identify need for dental providers.Write and place national urinal ads for November and December to target practicing dentists. OCTOBER – DECEMBER Continue dental provider training program visits. Meet with administrator to establish recruiting priorities for the coming calendar year and prepare for next month's provider recruitm ent committee meeting. Send letter of introduction to next year's graduating dental students (second letter to be sent in March). Contact academic dentists younger than 45 years. Mail letter to practicing dentists (second letter to be sent in January). Semi-annual provider recruitment committee meeting.Prepare medical staff survey to identify provider manpower needs and issues. Attachment 1 Graphic Summary of the Recruitment Process 1 . Preparation for recruitment 2. Prospects 3. Suspects 4. Applicants 5. Candidates 6. Finalists 7. Hired Develop health professional plan Identify new candidate Provide description of opportunity (sees) Provider sends C.V. In-depth phone interview Complete interviewing process Regular communication before start date Prepare practice assessment Targeted direct mail Determine interest/needs of providers C.V. screened according to criteria Prepare for site visitFinalize contract negotiations Professional orientation Determine role of current professional staff Display at professional assemblies Follow-up with requested information Candidate tracking & referral system Provide examination copy of contract Hospital privileges Determine salary and benefits Advertise Personal follow-up with candidate Develop in-house recruitment system Marketing introduction to professional sites Candidate tracking and referral system Develop promotional materials Direct contacts (cold calls) Reference & credential check Draft specimen contract Determine selection criteria

Leonardo vs. Michelangelo

Leonardo versus Michelangelo Violet Jane Greeley Art Appreciation ART 101 Carrie Ann Wills November 13, 2012 Da Vinci versus Michelangelo Leonardo da Vinci and Michelangelo di Lodovico Buonarroti Simone shared many similarities. Both were painters, sculptors, and poets. They both had a tendency to leave their works incomplete. Both artists quickly surpassed the talents of their instructors and achieved fame with ease. In addition, both artists were known to have studied anatomy by dissecting human cadavers [ (Bambach, 2002) ].Together they make up two thirds of the Renaissance’s three greatest artistic minds of all times, the other being Raphael. In this paper, I will first give a brief biography of each artist, then compare and contrast three works of art by Leonardo with three works of art by Michelangelo, followed by a discussion on how each artist made their own personal influence on the world of art in Italy and Europe during the 16th century, and provide supporting examp les. Leonardo was born on April 15, 1452 and passed away on May 1, 1519 [ (Helicon, 2005) ].Leonardo’s first painting and sculpting instructor was Andrea del Verrocchio, with whom he was apprenticed to and even surpassed in skill [ (Vasari, 2006) ]. During his apprenticeship to Verrocchio, Leonardo excelled at many skills including painting, sculpting, architecture, engineering, and mathematics [ (Vasari, 2006) ]. Still further, he studied subjects such as botany, geology, geography, zoology, anatomy, hydraulics and mechanics [ (Kleiner, 2010) ].Michelangelo was born on March 6, 1475 and passed away on February 18, 1565 [ (Jacobs, 1968) ]. When Michelangelo was fourteen years old, he was apprenticed to Domenico Ghirlandajo in April, 1488 [ (Vasari, 2006) ] [ (Gombrich, 1995) ]. Before long, Michelangelo excelled in his artistic ability, surpassed his fellow apprentices, and at times even rivaled his master’s abilities [ (Vasari, 2006) ]. Additionally, he achieved exemp lary skills in architecture, poetry, and engineering, but was most fond of sculpting above all else [ (Kleiner, 2010) ].Although Michelangelo wasn’t apparently influenced by Ghirlandajo in artistic methods or styles, his attitude and behavior reflected that of his master more prominently by his frequent displays of vigorous work ethics and an impatient temperament [ (Gombrich, 1995) ]. While under the tutelage of Ghirlandajo, Michelangelo carefully analyzed old and new artists and their techniques. These included but weren’t limited to Giotto, Masaccio, Donatello, Ghiberti, Benedetto da Majano, Mino da Fiesole, Antonio Rossellino and Jacopo della Quercia Rolland [ (Rolland, 1921) ].Florentines whose influence can be seen in Michelangelo’s works are Giotto and Masaccio [ (Kleiner, 2010) ]. A year after his apprenticeship to Ghirlandajo, he was also introduced to Bertoldo di Giovanni (who was himself once a student of Donatello) through Lorenzo the Magnificent, an d was instructed on the art of sculpture in the Garden of Medici as well as being influenced by Lorenzo de Medici [ (Kleiner, 2010) ] [ (Rolland, 1921) ].His original intent in joining with Giovanni was to gain experience with the tradition of Donatello and to enhance his knowledge of antiquities, but the most precious asset Michelangelo acquired from Giovanni was access to and the friendship of the Medici family [ (Rolland, 1921) ]. From 1492 to 1494, Michelangelo obtained an extraordinary opportunity to study anatomy in the hospital which was adjoined to San Spirito [ (Nickerson, 2008) ]. Vasari stressed the importance of studying antique forms and the significance of such in the work of all of the most highly regarded master artists in the High Renaissance era [ (Johnson, 2000) ].Leonardo, Raphael, and Michelangelo were no exceptions to this rule, and Michelangelo especially applied himself in that aspect [ (Johnson, 2000) ]. Leonardo was a major contributor to the art world in t he late 15th and early 16th centuries and a predecessor of many other artistic marvels including Raphael and Michelangelo. Here I will discuss St. Jerome in the Wilderness, The Last Supper, and Mona Lisa. St. Jerome in the Wilderness was begun in 1480 and is one of many of Leonardo’s unfinished products [ (Classics, 2012) ]. St.Jerome resides in the Vatican Museums in Rome [ (Classics, 2012) ]. St. Jerome withdrew from society into the Syrian Desert and became a recluse [ (Classics, 2012) ]. The painting illustrates a far off crucifix on the right side of the picture and St. Jerome kneeling down all the while fixing his eyes on the distant crucifix [ (Classics, 2012) ]. A rock can be seen in St. Jerome’s hand and a lion is close by [ (Classics, 2012) ]. The rock represents the object with which St. Jerome uses to punish himself for the purposes of atonement [ (Classics, 2012) ].The lion is indicative of the companion St. Jerome acquired after healing an injury to the l ions paw. A cardinal’s hat together with the lion and the stone are common traits associated with St. Jerome. Also on the right is a church between the rocks, the existence of which could indicate St. Jerome’s Doctoral position [ (Classics, 2012) ]. Leonardo used a fresh, new technique in positioning St. Jerome in a disproportionate way so that his figure was vastly different than that of the lion [ (Classics, 2012) ].Through the passage of time, this painting has endured separation and the process of reassembly [ (Classics, 2012) ]. The Last Supper came into creation beginning in 1495, was improved upon in sporadic periods, and was finished it in its entirety in 1498 [ (Classics, 2012) ]. Duke Ludovico Sforza and Duchess Beatrice d’Este commissioned The Last Supper who wanted it to be the centerpiece for the Sforza family mausoleum [ (Classics, 2012) ]. However, the painting now serves as the wall covering for the dining hall in the monastery Santa Maria del Gr azie [ (Classics, 2012) ].The Last Supper was an elaborately detailed representation of Jesus’ life as it neared its end in the Gospel of John chapter 13 verse 21. Jesus revealed his awareness of the upcoming betrayal from within his beloved discipleship as the Bible described the scene in the book of Matthew chapter 26, verse 21 [ (Kleiner, 2010) ]. The reactions of the disciples ranged in varying degrees of outrage, shock, horror, grief, and disbelief as continued in the book of Matthew chapter 26, verse 22 [ (Kleiner, 2010) ].Another reference to Biblical doctrine included in the painting was the initiation of the Eucharist in the book of Luke chapter 22, verses 19 through 20 [ (Kleiner, 2010) ]. In the painting, Judas was clearly stunned at the announcement of his plot [ (Classics, 2012) ]. In a state of reservation, he was grasping the money purse containing the silver which had been obtained in trade for the betrayal [ (Classics, 2012) ]. Some observers of the painting argue that the purse could also be suggestive of Judas’ status as treasurer of the group as well [ (Classics, 2012) ].Close observers may take note of Judas tipping over the salt shaker, which may be a cleverly disguised reference to a phrase which signifies the betrayal of a master [ (Classics, 2012) ]. Peter appeared to be perturbed all the while wielding a knife; this could have been a deliberate inclusion of the painting in order to give observers a sense of foreboding, a reminder of the violence to come in the midst of Jesus being arrested [ (Classics, 2012) ]. John was painted in a manner portraying him in the throes of a fainting spell [ (Classics, 2012) ].As was commonly practiced at the time, Leonardo positioned all of the disciples and Jesus on one side of the table for the purpose of being able to see them all [ (Classics, 2012) ]. Some other painters during later periods of time occasionally separated Judas from the other disciples by either seating him on the opp osing side of the table or by neglecting to give him a halo like the others in the painting, an obvious indication of his fall from grace [ (Classics, 2012) ]. Rather than denoting Judas in that way, Leonardo uses the shadows as a safe haven for the villain to conceal his own guilt in [ (Classics, 2012) ].Jesus could be seen in the painting as he pointed toward the bread and persisted in foretelling pending events by stating that the traitor would break of the bread simultaneously with himself as is suggested in the book of Luke chapter 22, verse 21 [ (Classics, 2012) ]. Judas reached for the bread as predicted because he was distracted by the conversation between John and Peter [ (Classics, 2012) ]. In this painting, the artist used a definitive method of manipulating the lighting which in turn naturally brought the observers eyes to the central focal point of the painting behind Jesus’ head [ (Classics, 2012) ].Because Leonardo used an alternative method of painting, The La st Supper rapidly began deteriorating [ (Classics, 2012) ]. Although efforts have been made to maintain its integrity, the quality of the painting has suffered substantially [ (Classics, 2012) ]. The deterioration so compromised the painting it can only be speculated upon that Leonardo originally intended for the positioning of Jesus’ feet to be suggestive of the forthcoming crucifixion [ (Classics, 2012) ].It’s quite apparent in this art piece that Leonardo did extensive research with the help of models and close observational skills to create a psychologically provocative and visually pleasing scene [ (Classics, 2012) ]. Mona Lisa otherwise known as La Gioconda was a portrait conceived in about 1503 and was completed in 1519 [ (Classics, 2012) ]. The commissioning was initiated by the woman in the painting, Lisa del Gioconda and her husband who was a prosperous silk merchant in Florence [ (Classics, 2012) ].In the beginning of its existence, Mona Lisa may have been h oused at Chateau Fontainebleau, but was then relocated to the Palace of Versailles, then to the Louvre where it remains to this day [ (Classics, 2012) ]. No other work of art in the world is more famous than Mona Lisa [ (Classics, 2012) ]. Lisa del Gioconda was a member of the Gherardini family, who were prominent Florentines [ (Classics, 2012) ]. The painting of this portrait was motivated by the acquisition of the couple’s new residence as well as in celebration of their second son having been born [ (Classics, 2012) ].Factors that aided in the promotion of this portrait gaining such colossal fame were the vague facial expression, the delicate method of painting the shapes, and the enormity of the composition [ (Classics, 2012) ]. In creating the Mona Lisa, Leonardo used a pyramid shape as a basis of effortlessly positioning the subject into the space permitted, with her hands folded demurely taking the shape of the obverse corner [ (Classics, 2012) ]. The lighting of the p ortrait gently caressed her in various places including her breast, hands, neck, and face, giving the painting added fundamental dimensions [ (Classics, 2012) ].Lisa held an erect posture, and her fixed stare was another distinct feature that gave the portrait its signature quality. The darker elements of the painting such as Lisa’s hair and veil along with the encompassing shadows help to add radiance to her face that might otherwise have been less noticeable [ (Classics, 2012) ]. Leonardo’s absence of outlining particular facial features enhanced the liveliness of the subject. As was typical of Leonardo, the comprehensive landscape, the general calmness, theatrical use of lighting and shadows, and the obscure outlining all contributed to this masterpiece [ (Classics, 2012) ].It’s important to note the background contained a visual illusion in that one side was significantly higher than the other which would be unfeasible in reality [ (Classics, 2012) ]. Howeve r because of the discrepancy, Lisa seemed to move or smile if the viewers eyes shifted from one side to the other [ (Classics, 2012) ]. The painting survived a number of attacks over a period of time including theft, an acid spill, stone throwing, and other such mishaps, but has been minimally damaged and on occasion repaired [ (Classics, 2012) ].Michelangelo created many great works in his time, and in conjunction with Leonardo and Raphael defined the artistic era of the Renaissance. I will focus on two of his statues; The Pieta and David, and one of his paintings; The Last Judgment. Before discussing Michelangelo’s statues, I’d like to restate that he’d previously gained extensive knowledge of human anatomy by secretly dissecting cadavers, which aided his ability to create accurate portrayals of human physique while sculpting and painting [ (Hartt, 1989) ].Since this practice was illegal as well as being considered morally corrupt behavior, having done so put him at an advantage over many other artists [ (Hartt, 1989) ]. Work on the Pieta, a life-size statue made of marble was set into motion in between 1498 and 1499 and reached its fruition in 1500 [ (Kleiner, 2010) ]. It was the French cardinal, Jean de Bilheres Lagraulas who commissioned the Pieta to be done so that it might enhance the appearance of the chapel in Saint Peters where he was intended to be buried [ (Kleiner, 2010) ].This statue, his first masterpiece was a representation of Mary holding Jesus after his crucifixion [ (Kleiner, 2010) ]. Controversy surrounded this work of art regarding Mary’s appearance of being younger than Jesus [ (Kleiner, 2010) ]. However the artist was able to portray Mary’s loveliness as well as her grief in an intensely vivid manner [ (Kleiner, 2010) ]. The artist’s intent in portraying such youth in Mary was that he’d been attempting to use that feature as a method of defining Mary’s purity.As a result of the you thful and tranquil appearance portrayed in the Pieta, Michelangelo’s statue was unique in comparison to other artists portrayals of the same scene in which their Mary was much older and broken-hearted. Michelangelo created such detailed imagery that the Pieta quite visibly displayed a variety of textures including hair, fabric, and flesh [ (Kleiner, 2010) ]. This particular piece of artistry in addition to David has been replicated by numerous other painters and sculptors.It’s been said that Michelangelo wasn’t initially in the habit of signing any of his pieces of artistry. However, upon hearing observers crediting other artists with his accomplishment he began doing so with the Pieta. The Pieta originally was destined to occupy Saint Peter’s Basilica in Vatican City, however it is now located in the church which took the place of Saint Peter’s [ (Kleiner, 2010) ]. Michelangelo’s David wasn’t the first statue of the biblical hero, bu t it was the most impressive one which has ever been created thus far [ (Kleiner, 2010) ].David was a popular biblical theme about a young shepherd boy purportedly the underdog who volunteered to enter into battle with a much larger adversary [ (Lee, 2004) ]. In this story, David defeated his enemy with a slingshot, his skill, and his courage as the only weapons at hand, without even being protected with armor [ (Lee, 2004) ]. Upon his return to Florence in 1501, Michelangelo received a warm reception regardless of his previous association with the Medici family [ (Kleiner, 2010) ]. He began sculpting David immediately and completed this work in 1504 [ (Kleiner, 2010) ].Donatello and Verrocchio both had previously created statues of David; however unlike Michelangelo, theirs were symbolic of the hero after his battle with Goliath [ (Kleiner, 2010) ]. Michelangelo created his personification of David to represent the events prior to the battle with Goliath [ (Kleiner, 2010) ]. He use d David’s anatomy to imbue strength, anticipation, and reserved energy [ (Kleiner, 2010) ]. He even added the minute detail of engorged veins to emit a sense of the physical process of an adrenaline rush and the psyche which accompanies it [ (Kleiner, 2010) ].David’s facial expression was indicative of having already decided to do battle, but not yet having completed the task. Clearly it was Michelangelo’s intent to portray David in the very moment in which the slingshot was about to be raised [ (Nickerson, 2008) ]. Michelangelo’s David possesses a poignant connection with an imperceptible presence [ (Kleiner, 2010) ]. It was unlike any other because of its overall size and slender physique, and to this day can be surpassed only by Michelangelo’s Pieta.Upon completion, this masterpiece further solidified Michelangelo’s reputation as a master sculptor and artist in all of Italy [ (Nickerson, 2008) ]. David is now located in Florence, and stan ds at an impressive fourteen feet high [ (Hartt, 1989) ]. Michelangelo’s knowledge of anatomy, balance, and proportion are prevalent, along with an aura of superhuman magnificence [ (Hartt, 1989) ]. David is but one example of Michelangelo’s personality which exemplified divine humanity [ (Hartt, 1989) ]. Divine humanity represented developing values in the Renaissance era [ (Hartt, 1989) ].The Renaissance began a movement away from centuries of control over human affairs on the part of the church and a restoration of humanistic values of the contemporary world [ (Hartt, 1989) ]. It was firmly held by Michelangelo that the human body was the living embodiment of God’s divine power [ (Hartt, 1989) ]. He successfully articulated man in its ultimately heroic status in creating his David sculpture [ (Lee, 2004) ]. The spiritual closeness Michelangelo held to was in direct contrast with the scientific approach of Leonardo [ (Hartt, 1989) ].Michelangelo began painting The Last Judgment in 1536 and completed it in 1541 [ (Kleiner, 2010) ]. In the midst of his work, the counter-reformation was in full force [ (Kleiner, 2010) ]. An important issue affecting the world of art was the difference in religious beliefs between the Catholics and the Protestants [ (Kleiner, 2010) ]. The Catholics valued artwork for its power to manipulate the people toward piety [ (Kleiner, 2010) ]. Protestants, on the other hand found artwork to promote idolatry and distraction [ (Kleiner, 2010) ].To alleviate controversy regarding this issue, the Catholic Church reached an agreement that images should be visually and theologically unambiguous [ (Kleiner, 2010) ]. The uproar of the counter-reformation was instrumental in Michelangelo’s decision to paint the altarpiece of the Sistine Chapel, The Last Judgment as a way of depicting the controversial times. The central figure of the altarpiece was the Lord, and all around the Christ figure were nudes. God was the unyi elding authority over his human subjects, and physically gestured his intent to utterly annihilate humanity [ (Kleiner, 2010) ].It’s quite clear that the Lord had complete control over the destiny of all of the spirits around him. The Heavenly hosts emanated their unease, while angels trumpeted, and the Lord discerned between the just who ascended to Heaven and the damned who were thrown into the pits of Hell [ (Kleiner, 2010) ]. Michelangelo further purveyed horror by including rising dead figures and demons provoking great suffering and agony upon the damned souls [ (Kleiner, 2010) ]. Other known figures which complement this masterpiece were Saint Bartholomew and who was either the good thief or St. Andrew [ (Kleiner, 2010) ].The works of da Vinci and Buonarroti significantly influenced the world of art in the 16th century in Italy and Europe in numerous ways. The two artists shared many similarities in talent and scope of knowledge; however it was their individual uniquen ess that magnified their works to the status of masterpieces in their lifetimes and beyond. In 1476, Leonardo was permitted to paint an angel in Verrocchio’s Baptism of Christ, in which he impressed his master with his superb display of talent [ (Jacobs, 1968) ]. By that point in time, he’d already been elected to be a painter into the painter’s guild [ (Jacobs, 1968) ].Other contemporaries alongside Leonardo under Verrocchio’s tutelage included such notable artists as Perugino and Lorenzo di Credi [ (Johnson, 2000) ]. By the year 1481, Leonardo’s talent was known all over Italy, and he was commissioned by the Saint Donato monastery to paint their altarpiece which is now known as The Adoration of the Kings [ (Jacobs, 1968) ]. However as was Leonardo’s tendency, he neglected to complete the altarpiece and sought employment with Ludovico Sforza, Duke of Milan [ (Jacobs, 1968) ]. His first work for the Duke was to create a statue of Ludovicoâ⠂¬â„¢s father.Approximately in 1496, Leonardo began planning and painting his famous Last Supper located in the Santa Maria delle Grazie, which took about two years to complete [ (Jacobs, 1968) ]. Around the year 1500, he created the painting known as The Battle of Anghiari, and soon after embarked on his most famous work, Mona Lisa [ (Jacobs, 1968) ]. Francois I was among the first patrons to passionately support the coming of the Renaissance to France and commissioned Leonardo to work around the year 1516 along with other prominent figures such as Rosso Fiorentino [ (Johnson, 2000) ].Following this event, he then created two more paintings for the French viceroy in Milan, The Virgin of the Rocks, and Saint Anne with the Virgin and the Infant Christ that ended up being his last masterpieces [ (Jacobs, 1968) ]. Almost two centuries later, another artist known as Diego Velazquez would use similar painting techniques to Leonardo in which he wasn’t as concerned with every minute detail of a subjects being so much as capturing their characteristic impressions [ (Gombrich, 1995) ].Leonardo was also the mastermind of a device known as sfumato which was used by many other artists who followed him even centuries later in order to overcome the problem of naturalism and perspective creating a rigid and wooden appearance on the subjects of the paintings [ (Gombrich, 1995) ]. Unfortunately, another problem arose which this technique could not accommodate. The shadows used by Leonardo didn’t naturally occur in the light of day, therefore Impressionist artists had to resort to blurring some aspects of their painting to prevail over the dilemma [ (Gombrich, 1995) ].Michelangelo learned the fresco technique from his original instructor, Ghirlandaio [ (Jacobs, 1968) ]. Later on, he was sent to the Medici Garden where he learned from Bertoldo di Giovanni [ (Jacobs, 1968) ]. While in the presence of the Medici family, Lorenzo de Medici encouraged Michelangelo to in volve himself in conversations with many of the most renowned men of the time [ (Jacobs, 1968) ]. He achieved recognition for his talent in approximately 1492 when he constructed his first masterpiece The Battle of the Centaurs, which was a marble relief [ (Johnson, 2000) ].This statue remains unfinished as are many of Michelangelo’s works of art. By 1499, Michelangelo succeeded in creating a superb statue known as Pieta, which was completed in 1499 and caused him to gain world-wide recognition [ (Jacobs, 1968) ]. In the next few years, he occupied his time by creating a statue of David, in the Accademia, Florence [ (Jacobs, 1968) ] [ (Johnson, 2000) ]. Michelangelo’s depiction of David dwarfed those of Donatello and Verrocchio in ability, and talent. His next project, the tomb of Pope Julius II was to be the longest lasting one of his life, taking a full forty years to complete [ (Jacobs, 1968) ].One statue included in this great endeavor is Moses, arguably the most e xcellent work exhibited by this particular sculptor [ (Johnson, 2000) ]. The tomb also includes The Atlas Slave (incomplete), The Dying Slave, and a statue of Lorenzo de Medici, along with two supporting nudes below [ (Johnson, 2000) ]. In the midst of his work on the tomb of Pope Julius II, he worked on the Sistine Chapel ceiling from May 10, 1508 until October 31, 1512, this also being done for Julius II [ (Rebman, 2000) ]. This particular masterpiece is to this day incomparable to any other work of art [ (Rebman, 2000) ].Pope Julius II chose to employ Michelangelo for this task because his reputation throughout Italy and Europe was that of an outstanding sculptor who had an exceptional talent for using physical forms to express his own feelings and emotions [ (Rebman, 2000) ]. The ceiling of the Sistine Chapel in its entirety contains nine major panels; God Separating Light from Darkness, The Creation of the Sun, Moon, and Stars, The Separation of Land from Water, The Creation of Adam, The Creation of Eve, The Temptation and Fall of Adam, The Sacrifice of Noah, The Flood, and the Drunkenness of Noah [ (Rebman, 2000) ].Twenty four years later, Michelangelo was commissioned by Pope Paul III to paint a mural above the altar of the Sistine Chapel which was to be a companion piece to the ceiling; The Last Judgment [ (Jacobs, 1968) ]. This altarpiece took him six years to complete beginning in the summer of 1536 and reaching its completion on October 31, 1541 [ (Rebman, 2000) ]. According to records, Michelangelo employed a single assistant for this project; Urbino, a talented artist who showed a significant ability with the foreshortening technique [ (Rebman, 2000) ].Numerous authorities on the matter believe Michelangelo’s source of inspiration for The Last Judgment was derived from a poem, The Divine Comedy written by Dante who mentioned a Charon and Minossis both of whom are included in the painting [ (Rebman, 2000) ]. Much praise and criticism was hea rd for this painting, ranging from amazement and wonder to abhorrence for the scandalous nudity [ (Rebman, 2000) ]. Biago da Cesena was one of the first among many who offered scathing disapproval of the nudity of the figures [ (Rebman, 2000) ].As a result, Michelangelo painted the face of Biago on the figure of Satan and a serpent slithering about the body while biting the groin area of Satan [ (Rebman, 2000) ]. Despite Biago’s complaints to the Pope, the painting remained as it was [ (Rebman, 2000) ]. Unfortunately, due to so much criticism over the nudity of the painting, modifications were later made by Daniele da Volterra, who was hired by the church officials to paint clothing on the genitals of the nude figures [ (Rebman, 2000) ]. However, another artist, Martino Rota made an engraved replica of the original Last Judgment prior to the alterations [ (Rebman, 2000) ].Similar to the habits of Leonardo, Michelangelo frequently abandoned his paintings before completing them , and the only known finished easel painting is The Holy Family [ (Jacobs, 1968) ]. Michelangelo’s reputation was far superior to those of his contemporaries in sculpture, even including the next generation [ (Johnson, 2000) ]. Many new and upcoming artists studied Michelangelo’s methods with great intensity, and strived to imitate his level of distinction by painting nudes in their own works of art as he had done [ (Gombrich, 1995) ].These artists seemed to have overindulged themselves in this practice, and such behavior took away from the meaning of the paintings rather than adding to it [ (Gombrich, 1995) ]. This fashion became known as Mannerism. In closing, I’ve mentioned a few similarities common between both Leonardo da Vinci and Michelangelo di Lodovico Buonarroti Simone. In addition, I gave a summary of each artists lives, compared a few of their art pieces, and finished off with a discussion on how each artist made their own personal influence on the w orld of art in Italy and Europe during the 16th century with supporting examples.References Bambach, C. 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